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Effective antioxidants, including stable glutathione compounds, analogues of superoxide dismutase, and selenium-based drugs, have been developed for clinical use [123]

With the development of time and technology, immunotherapeutic approaches for various leukemias have shown great promise, such as CD33 or CLL-1-specific chimeric antigen receptor (CAR)-T cell therapy[2, 3] and immune checkpoint inhibitor therapies such as TIM3, CD47, and anti-CD70 [4,5,6]

According to Cant et al., Cell Metabolism , increased NAD stimulates PGC-1 activity, driving mitochondrial biogenesis and substrate flexibility

The simultaneous application of probiotics and dietary interventions is likely to be a safe and effective adjuvant therapy but its use in the clinic has to address issues of formulation standardization, patient suitability, and long-term safety

This activation triggers protein kinase C (PKC) and mobilizes intracellular calcium reserves through the inositol trisphosphate/diacylglycerol pathway