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In this context, the increased extracellular glutamate can bind to its receptor, the metabotropic glutamate receptor 5 (mGluR5) on the stellate cell surface, stimulating it to synthesize 2-arachidonoylglycerol (2-AG) [155], which in turn, once released into the extracellular space, binds to the cannabinoid receptor-1 (CB1R) on hepatocytes, triggering a mechanism of de novo lipogenesis and therefore of fat accumulation [156] (Figure 7)

[DOI] [PubMed] [Google Scholar] 128.Bernard B, Grang JD, Khac EN, Amiot X, Opolon P, Poynard T

J.WilsonS

Sheet Type: Soft cellulose sheet that offers strong, comfortable adhesion for better serum delivery

GCH1-mediated BH4 synthesis reprograms lipid metabolism and inhibits ferroptosis by selectively preventing two polyunsaturated fatty acyl tails from depleting PLs (Kraft et al., 2020)