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Statements Author contributions CA provided the first draft of the manuscript and the tables and figure

U937 cells expressing lentiCas9-Blast were used to generate clonal lines of KIAA1109 KO with the sgRNAs targeting sequences GCCAGCTACCCCCGAATAtgg and GTTGACATCTACTACTACAtgg

In a study using a rotenone-induced PD mouse model, combined with antibiotic-induced microbiome depletion and fecal microbiota transplantation, it was found that gut microbiota dysbiosis, along with leaky gut-induced bacterial endotoxins, activates C/EBP/AEP signaling and -syn pathology, ultimately leading to neurodegeneration in PD (52)

Tsilioni I, Natelson B, Theoharides TC

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