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You can run continuous cycles for up to 6 months without mandatory breaks, but receptor sensitivity may plateau after 45 months of nightly dosing

Specific digestive enzymes, most notably gamma-glutamyltransferase (GGT) and various intestinal peptidases, cleave the tripeptide into its constituent amino acids long before it can reach systemic circulation intact

Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines in chronic kidney disease: a clinical approach

PMID 32734307

Once formed, superoxide radicals are dismutated in mitochondria by manganese superoxide dismutase (MnSOD) to hydrogen peroxide (H 2 O 2 ) and molecular oxygen (O 2 ), or react with endogenous nitric oxide (NO) to form peroxynitrite (ONOO ) [50]