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The increased sugar concentration in the blood causes hyperperfusion and hyperfiltration of the glomeruli, as well as excessive tubular reabsorption, leading to an increase in renal oxygen consumption

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As GSTT1 protein is not expressed on the cell surface, recognition likely takes place in the extracellular compartment after cell apoptosis induced by ischemia-reperfusion or other tissue damaging noxae, such as calcineurin inhibitor toxicity or an inflammatory process

MMP-2: is too low as bad as too high in the cardiovascular system

doi: 10.3389/fncel.2025.1593963 Received 15 March 2025 Accepted 27 June 2025 Published 22 July 2025 Volume 19 - 2025 Edited by Alessandro Tozzi, University of Perugia, Italy Reviewed by Antonio Martnez-Ruiz, Princess University Hospital, Spain Mingzi Zhang, University of Southern California, United States Walter Moos, University of California, San Francisco, United States Updates Copyright 2025 Huang, Zhang, Chen, Wang and Zhou