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TB-500 is a 43-amino-acid synthetic fragment of thymosin beta-4, a small protein originally isolated from calf thymus tissue

The peptide enhances expression of key transcription factors including Lhx2 and Sox9 essential for hair follicle stem cell maintenance and activation while modulating Wnt/-catenin signalinga critical pathway for hair follicle morphogenesis and cyclingwith treated follicles showing enhanced -catenin nuclear localization and increased Wnt target gene expression

Note the larger hair follicles (elongated columns) in the lower photo, the increased content of subcutaneous fat in the skin (white material in the center of the skin), and the increased thickness of the skin

& Shiiba, M

Many patients report early improvements in gut comfort and reduced skin irritation within the first one to two weeks