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however, safety concerns still accompany this therapeutic approach

The present strategy therefore has been to enhance the activity of endogenous HGF instead of devising methods of HGF delivery

221 Accordingly, BRAF, ARID1A, RNF43, and KM2B with higher mutation frequencies can be used to predict the prognosis and distinguish MSI from MSS tumours, and they provide guiding significance for the clinical effect of immunotherapy in MSI CRC

However, after moderate cooling to 28C, this vasoconstriction is exclusively mediated by the activation of 2C -ARs, which are otherwise silent (Jeyaraj et al., 2001