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Since 1990, significant advances have been made in phosphor- and phosphon-amidate analogs, and it is important to note the only US FDA-approved phosphonate prodrug since 2007, tenofovir alafenamide, includes an amidate moiety [1,81]

At the same time, major biosynthetic processes, such as protein or RNA synthesis, are not active in dormant cells according to the low bacteriocidic activity of the corresponding antibiotics targeting these cells ( Table 1 )

A total of 8 non-trivial lethal double gene combinations satisfied this criterion (see Table 2 for list of synthetic lethal targets)

For straightforward single rib injuries, BPC-157 alone may provide sufficient support

Lee JS, Kim HG, Han JM, Kim DW, Yi MH, Son SW, et al