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PRKN blocks SREBF2/ACAT2 signaling-mediated CC cell proliferation and immune evasion CCK8 and colony formation assays corroborated that PRKN overexpression inhibited CC cell proliferation, and the promoting effects of SREBF2 on CC cell proliferation were reversed by ACAT2 knockdown again (Fig

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This and many other hitherto uncharacterised factors induce accumulation of pathogenic inclusions differently termed as Lewy bodies in neurons of PD patients (Marotta et al., 2021) or glial cytoplasmic inclusions in oligodendrocytes of Multiple System Atrophy (MSA) patients (Reddy and Dieriks, 2022)

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