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Understanding different resistance mechanisms to currently-existing inhibitors can provide new insights into combinatorial targeting of the driver oncoprotein and further downstream effectors to avoid or postpone the therapy resistance

doi: 10.21577/0103-5053.20190163

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In the N-acetyl form, an acetyl group is added to the N-terminus of the four-residue chain, a modification commonly used in peptide chemistry to alter charge, lipophilicity, and resistance to aminopeptidase activity relative to the unmodified peptide

& Arafat, E