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It is now considered the most abundant isozyme of the GPx family and is present ubiquitously in all the tissues of human origin [1, 8, 9]

Obviously, PQQ has been proved to attenuate oxidative stress in mitochondria 44,89 , and antagonize glutamate-induced neuronal injury both in vitro and in vivo 17,90,91

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J Appl Biochem 5:4352 Hibi T, Nii H, Nakatsu T, Kimura A, Kato H, Hiratake J, Oda J (2004) Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis