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Since the development of affinity chromatography in the early 1950s, various types of target proteins for bioactive compounds have been isolated and identified

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Mitophagy-related regulated cell death: molecular mechanisms and disease implications

Nevertheless, these drugs are associated with significant cytotoxic effects, including nephrotoxicity, neurotoxicity, pancytopenia, alopecia, gastrointestinal discomfort, compromised fertility, and allergic reactions in the epithelial tissue

Luteolin and sorafenib combination kills human hepatocellular carcinoma cells through apoptosis potentiation and JNK activation