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Via a porin channel, acylcarnitine crosses the inner mitochondrial membrane in exchange for a carnitine molecule in the opposite direction, thus ensuring that the mitochondrial carnitine concentration remains constant

Results were presented as mean values standard deviations (SDs)

The % Cytotoxicity was calculated using the following formula: L-carnitine oral challenge Seven weeks before the start of the study, mice were housed in groups of four according to sex, APOE genotype, and treatment group (Supplementary Table S3)

The metabolic consequences of hepatic androgen exposure extend beyond the liver itself

Then, increases in malonyl-CoA concentrations ultimately suppress FAO through CPT1 inhibition, completing the switch from fat to glucose oxidation