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The shift doesn't have to be dramatic

Thioflavin T binds to amyloid fibrin clots and allows them to be visualized through fluorescence microscopy (Pretorius studies reference)

The percentage of malformed fetuses per litter also was increased in a dose-related manner at doses of up to 5 g per fetus

10.1021/js980086i [DOI] [PubMed] [Google Scholar] Zhang Y., Bonzo J
Mechanisms of age-related macular degeneration
