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Europ J of Orthop Surg Trauma
M1 macrophages are mainly regulated by transcription factors such as nuclear factor kappa B (NF-B), signal transducer and activator of transcription 1 (STAT1), signal transducer and activator of transcription 3 (STAT3), interferon regulatory factor 5 (IRF5), and hypoxia-inducible factor 1-alpha (HIF-1)
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Due to its shorter sequence, TB-500 offers enhanced metabolic stability and amenability to synthetic optimization compared to the parent protein
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