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10.1016/j.jacc.2020.07.033 [DOI] [PubMed] 86.Ueland T, Butt N, Lekva T, rn S, Manhenke C, Aukrust P, et al
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After 12 weeks across the entire set of subjects, mental fatigue showed a statistically significant decrease, with a 13.4% decrease in the L-carnitine group (4.5 to 3.9) compared to a 9.5% increase in the placebo group (4.2 to 4.6, p 0.05)
Together, these findings demonstrated that oxidative stress response pathways, including those involving SKN-1, SEK-1, and HLH-30, are critical for lifespan extension on both mutant diets and iron-depleted conditions
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