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Certain NPs, especially those composed of metals or non-degradable synthetic materials, have been shown to activate microglia and astrocytes, promoting the release of pro-inflammatory cytokines and ROS [167, 168]

247,248,249 However, these associations were not observed in non-European populations, underscoring potential ethnic differences in genetic susceptibility to hyperuricemia-related metabolic abnormalities

Please consult your doctor regarding use in pregnant females