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[DOI] [PubMed] [Google Scholar] 95.L A, Mantel M, Marchix J, Bodinier M, Jan G, Rolli-Derkinderen M

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These enhancements produce a sustained satiety signal and more pronounced glucagon suppression, enabling mechanistic studies of prolonged amylin pathway activation

Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased