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Histone-related genes include Hist1h2ai, H2afx, H3f3b 53

Acknowledgements This work was supported by National Natural Science Foundation of China (82170873, 82371424), and Tsinghua University Spring Breeze Fund (20211080005)

In contrast, astrocytes exhibit lower expression of pyruvate dehydrogenase (Laughton et al., 2007), which limits oxidative phosphorylation (Itoh et al., 2003) and reduces pyruvate utilization efficiency in the TCA cycle (Rahman et al., 2020)

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