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Tyrosine can be produced from phenylalanine metabolism and is required for the production of melanin and the catecholamines

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The disulphide bond-containing loop structure may require slightly longer to fully dissolve than linear peptides

Pietras A, Katz AM, Ekstrm EJ, Wee B, Halliday JJ, Pitter KL, et al

The other two are cis -acting regulatory mutations affecting expression of the Gata1 gene, which have been shown to cause acute erythroblastic leukemia and myelofibrosis in mice
