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Treatment is provided only after clinical review by a licensed provider

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Early human research is still limited, so larger randomized studies are needed to confirm these effects

Chronic Ca 2+ leak via dysfunctional RyR2 depletes Ca 2+ store in the SR, lowers Ca 2+ transient amplitude in systole and reduces cardiac contractility ( 2+ leak can lead to elevated Ca 2+ levels in diastole, impairing myocyte relaxation