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In contrast, male rats showed no behavioral despair but did present anhedonia (Rubino et al
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In summary, there are several topical therapeutic approaches aimed at targeting oxidative stress in DED include the reduction of inflammation and the enhancement of antioxidative defense mechanisms

Lipid profiles in schizophrenia associated with clinical traits: a five year follow-up study
Furthermore, studies of IGF-2 gene in transitional cell carcinoma of the bladder and MGMT gene in gastric cancer showed that patients with CT or TT MTHFR genotypes had reduced methylation of IGF-2 or MGMT compared those with CC genotype 36,37