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Maqbool M, Mobashir M, Hoda N (2016) Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimers disease

They are members of the immunoglobulin superfamily and include 3 transmembrane proteins JAM-A, -B, and -C (also called JAM-1,2, and3) characterized by a short N-terminal portion, two extracellular immunoglobulin-like loops, a transmembrane portion, a short cytoplasm fragment containing phosphorylation sites and a C-terminal PDZ domain involved in cell-cell adhesion (67, 112)

Thats because utilization of vitamin B12 (especially from supplements) depends on levels of other metabolic cofactors and acids

Annual review of microbiology , 54, 439461

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