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It supports various immune functions by enhancing the production and function of leukocytes, particularly lymphocytes, and promotes differentiation of monocytes into macrophages [263,264]

In this context, several sensors and pathways regulating the transcription factors, such as activator protein 1 (AP-1), cAMP response element-binding protein (CREB), hypoxia inducible factor-1 (HIF-1), nuclear factor B (NF-B), activating transcription factor 4 (ATF-4), and nuclear factor-erythroid 2-related factor-2 (Nrf2), have been described (Marinho et al

Such personalized treatment plans may also integrate diagnostic approaches, including miRNA profiling and customized delivery systems, solidifying the commercial value and market potential of IGF-1 as a basis for innovative hair restoration solutions [61,76]

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