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Change history 03 April 2019 A correction to this article has been published and is linked from the HTML and PDF versions of this paper

48 Given the altered participation coefficient patterns, the roles of inferior frontal gyrus and orbitofrontal cortex may shift from provincial hubs to connector hubs in ADHD, 49 representing compensatory adaptation to reduced processing capacity in other nodes, manifesting as early increases

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Treatment strategies aiming to interfere with the formation of amyloid (A) plaques and neurofibrillary tangles (NFTs), the two major AD hallmarks, have shown modest or no effect

Thus, depending on the make up of the transcription factors bound to the ARE, opposite effects may occur