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Dahl D., Onishi Y., Norwood P., et al., Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS5 Randomized Clinical Trial, Journal of the American Medical Association 327, no

Subcutaneous injection offers bioavailability of approximately 15-20% based on animal data, while intramuscular administration may provide 45-50% bioavailability in some species

Typical dosing starts at 0.05-0.1ml once weekly and then titrated up

10.1038/ejcn.2017.132 [DOI] [PMC free article] [PubMed] [Google Scholar] Smeyne M., Smeyne R

The problem, he said, is the hype around BPC-157 can be quite misleading, particularly when it comes from his fellow physicians