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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations IBS, Irritable bowel syndrome

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PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 62 H 98 N 16 O 22 Weight: 1,419.53 g/mol CAS: 137525-51-0 Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Readily dissolves in water Stability: Stable across various pH conditions Storage: Keep refrigerated 3646 F (28 C)

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