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doi: 10.1177/0269881114552744

As a result, a patient experiences a rapid, beneficial effect from the B12 deficiency treatment

Removal of the second-sphere influence of the on-face hydrogen bond between the hydroxyl groups T13 as in the T13V and T13A mutants elevates the pKa of enzyme-bound GSH by about 0.7 pKa units

A randomized, placebo-controlled study in 52 subjects (mean age, 30 years) with relapsing-remitting multiple sclerosis found an increase in total antioxidant capacity in blood with lipoic acid supplementation (1,200 mg/day for 12 weeks) yet not in the activity of specific antioxidant enzymes (superoxide dismutase and glutathione peroxidase) (97)

GOT2 silencing also significantly inhibited cellular ATP production and cell proliferation, indicating suppression of mitochondrial respiration (109)