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Hemolysis can occur within (intravascular hemolysis) or outside the blood vessels (extravascular hemolysis)

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Alternatively, APP can be cleaved by BACE-1 (-site APP cleaving enzyme) to generate the sAPP ectodomain and a 99 amino-acid C-terminal membrane-bound fragment that is further processed by the -secretase complex to generate A peptides (most commonly A40 and A42) and the intracellular APP domain [117]

plots concatenated from one experiment (nave, MCMV and vCD44BP, n = 4/group) and representative of four independent experiments