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Nuts and Bolts of Watch and Wait/Nonoperative Management in Rectal Cancer, US

Botha MH, Rajaram S, Karunaratne K (2018) Cancer in pregnancy

Moreover, excessive reactive oxygen species (ROS) and inflammatory cytokines secreted from macrophages and other immune cells [e.g., interferon- (IFN) and tumor necrosis factor (TNF)] can arrest the anagen phase, driving premature telogen and catagen phases, inducing apoptosis in the follicular microenvironment, leading to miniaturization and reduced hair density [2, 4, 5]

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