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These drugs can be broadly classified into three categories: cytotoxic agents , targeted therapies , and hormonal therapies

Temozolomide (TMZ) was recently approved for use in the treatment of malignant gliomas as an oral chemotherapy agent

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

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This nanosystem, featuring oral bioavailability, sustained release, and targeted delivery, synergistically combines the advantages of its individual components