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Tumor glutamate levels were measured from multiple animals for each treatment condition (Additional file 4: Figure S4C)

p53 gene mutations in human premalignant and malignant tissues

10.3389/fnana.2015.00091 [DOI] [PMC free article] [PubMed] [Google Scholar] Bortolotti M., Polito L., Battelli M

severe, 3.0 comorbidities), including anxiety (27%), obesity/overweight (26%), depression (25%), chronic gastrointestinal diseases (22%), and high cholesterol (22%) or CVD, including hypertension (20%)

While these preliminary findings suggest potential benefit, larger randomized, placebo-controlled trials are necessary, and at present there is insufficient evidence to make strong recommendations regarding the clinical use of acamprosate or other GABAergic agents in ASD (181)
