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Stress-induced Ca 2+ spikes serve as secondary messengers, activating calcium-dependent protein kinases (CDPKs) and calcineurin B-like proteins (CBLs) that regulate stress-responsive gene expression (Jain et al., 2018)

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This mutation refers to the inability of MTHF-R gene to activate folic acid to its active and usable form, 5-MTHF

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Antioxidants are crucial in preventing oxidative stress injury

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MASLD substudy: 82% liver-fat reduction at 24 weeks

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