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* Correspondence: Yazhou Ren [email protected] Mingqing Dong [email protected] These authors have contributed equally to this work ORCID Mingqing Dong orcid.org/0000-0001-9720-535X Yazhou Ren orcid.org/0000-0001-5361-3458 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Lumacaftor-ivacaftor (Orkambi) for cystic fibrosis: behind the breakthrough