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To further understand the molecular mechanisms underlying the function of eukaryotic steroid reductases and, in particular, the catalytic mechanism of SRD5As and the action of 5ARI drugs, we solved a crystal structure of human SRD5A2 in the presence of NADPH and finasteride

10.5114/aoms.2013.34415 [DOI] [PMC free article] [PubMed] [Google Scholar] 62.Amcoff K, Cao Y, Zhulina Y, Lampinen M, Halfvarson J, Carlson M

doi: 10.1016/j.ejphar.2018.07.002

Avnir Y, Turjeman K, Tulchinsky D, Sigal A, Kizelsztein P, Tzemach D, Gabizon A, Barenholz Y

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences