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is supported by Shanghai Science and Technology Commission Guidance Project 18411968200, Medical-Engineering Joint Funds of Shanghai Jiao Tong University YG2017MS81, Shanghai Chest Hospital Project of Collaborative Innovative Grant YJT20191015, Shanghai Youth Top Talent Project, and Shanghai Pujiang Talent Program (Grant No
Additionally, NRF2 activators such as bardoxolone methyl may enhance cellular antioxidant defenses, reducing ferroptosis-mediated skin damage

Image items used in this work were created in BioRender: Ethics declarations Competing interests The authors declare no competing interests

ThT@GMP/Eu, thioflavin T@GMP/Eu

Overall, these studies demonstrate that Mtb infection alters glutamine metabolism in infected macrophages, mice, and TB patients, and hence modulation of the glutamine levels and/or metabolism has the potential as an effective host-directed therapy