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Inverse variance weighting (as main analysis), weighted median estimate, robust adjusted profile score, MR-Egger, and MR-PRESSO (sensitivity analyses) were performed to calculate causal estimates

In general, epidemiological evidence suggests that the benefits of B vitamins extend well beyond the accepted biochemical cut-offs for deficiency or marginal deficiency and that consuming the RDA for some B vitamins would still leave large proportions of the population at risk of insufficiency

2019 Dec 1;7(4):397-403

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MOTS-c has a circulating half-life of approximately 2 to 4 hours