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47,48,49,50,51,52,53,54 All these studies used injectable B12, most commonly given intravenously (i.v.) after HD twothree times per week, and the most common dose was 1000 g per injection

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The consequences of NNMT overexpression create a metabolic feedback loop that promotes and maintains obesity

Future studies will be focused on optimizing the MQ-scaffold lead series to generate more potent NNMT inhibitors with significantly improved drug-like ADME profile