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Interestingly, attack by acetic acid takes place with preference at the epoxide carbon, which is most distal to the double bond (C-9 in the 9(10)-epoxides and C-13 in the 12(13)-epoxides)

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Recent studies demonstrated that NGS could provide a comprehensive assessment of thalassemia screening strategies with its superiority in for both sensitivity and specificity, indicating that NGS is a competitive screening method, especially among populations with a high prevalence of disease [85]