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Glutamate Synthesis, Release, Uptake, and Metabolism Glutamate is one of the so-called nonessential amino acids1that is, the cells can generate (i.e., synthesize) glutamate from other molecules, primarily -ketoglutarate and glutamine (Nicholls 1994) (figure 1)

J Bone Joint Surg Br

10.1593/tlo.11265 Transl

The results have revealed that BaP exposure reduced DNA methylation pattern in the promoter region of the CYP1A1 gene which accelerate the metabolism of toxins, but it has been noted that GSTP1 showed increased methylation which reduce its expression that is in turn lead to suppression of detoxification ability (Liu et al., 2022a)

146 OsakabeN.YamagishiM.NatsumeM.YasudaA.OsawaT