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(2020) Local administration of methylcobalamin for subacute ophthalmic herpetic neuralgia: a randomized, phase III clinical trial

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Statistically, this was reflected in a highly significant main effect of baseline versus post-test in the ANOVA, ( F (1, 31) = 10.45, p = 0.003, p 2 = 0.252), a non-significant t -test in the placebo condition ( t (6) = 0.65, p = 0.54, d = 0.25), and significant t -tests in both the Vitamin-B6 condition ( t (14) = 2.49, p = 0.026, d = 0.64) and the Vitamin-B12 condition ( t (11) = 3.11, p = 0.01, d = 0.90)

These findings (equal damaging effect of cysteamine, equal protection of NaBPC157 and reference agents in gastrectomized rats with intact stomach and without stomach, the damaging or protective effect is not related to gastric acid secretion) are indicative of a cytoprotective effect