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DNA primase is a heterodimer with a small and large subunit with the small subunit being responsible for RNA polymerase activity and the large [4Fe-4S] subunit (PRIM2) being responsible for DNA binding ( 2+ resting state where it is loosely bound to DNA, however, an oxidation of the cluster to a [4Fe-4S] 3+ state results in tight DNA binding (OBrien et al., 2017

Protein also makes a lot of other things in the body

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Sex Representation in Clinical Trials Associated with FDA Cancer Drug Approvals Differs Between Solid and Hematologic Malignancies

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