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Nutrients , 17 (13), 2069

47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG

Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer

Moreover, the amide group from glutamine can also be transferred to formylglycinamide ribonucleotide (FGAR), which subsequently forms phosphoribosyl-formylglycinamidine (FGAM) through the catalytic activity of 5'-phosphoribosylformylglycinamidine synthase (PFAS) during nucleotide synthesis

larval and juvenile stages typically exhibit narrower thermal tolerance windows than adults, constraining population renewal dynamics ( Recent analyses reveal that amphibian species in tropical regions are already operating near their thermal tolerance limits