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Targets aging at the source
A20 ameliorates advanced glycation end products-induced melanogenesis by inhibiting NLRP3 inflammasome activation in human dermal fibroblasts
In another work, knockout of the EAAT2/GLT1 gene in mice caused epileptic seizures and brain injury [52]
A CDCP1FTL CAF subset maintains iron homeostasis by upregulating ferritin and System Xc while reducing PUFA enrichment, and under hypoxia promotes Tregs and myeloid-derived suppressor cells (MDSCs) expansion, driving immune escape [153]
Mn-induced ER stress may also be a catalyst for apoptosis
