bpc-157 safety side effects BPC-157: Tendon Repair and More Regeneration or Risk? A Narrative

In a 2017 study using human vascular endothelial cells and a chick chorioallantoic membrane assay, Hsieh and colleagues reported that BPC-157 exposure increased VEGFR2 mRNA and protein expression, promoted VEGFR2 internalization (an effect blocked by the endocytosis inhibitor dynasore), and time-dependently activated the VEGFR2-Akt-eNOS axis without a corresponding increase in VEGF-A (Hsieh et al., 2017)

Another reason location matters is consistency

Energy low, insomnia keeping you awake, fatigue

It was suggested that it could be injected just under the skin near the belly button and may have helped with injuries around the body, systemically targeting inflammation

The peptides for joint and tendon repair research overview covers the localized versus systemic considerations