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Other drugs, such as all-trans retinoic acid (ATRA), have also been reported to restore activated PSC to a quiescent state and increase chemosensitivity in PDAC 51

A study in 2022 used this model to screen out a novel ALK5 inhibitor, TP-008, which reduced collagen deposition in mouse pulmonary fibrosis models by 70% (Luttens et al., 2025)

In addition to the GSH system, the brain employs other endogenous antioxidant mechanisms

& Tay, S
