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Therefore, the in vitro alkaline comet assay with liver tissue (PCLiS) and liver cell models (PHH, PRH, and HepG2 cells with 10% rat or hamster S9-mix) were evaluated as potential mammalian cell-based tools for prediction of genotoxicity of NAs, as proposed in a recent study (Seo et al

Given their separate mechanisms, any potential interactions are purely speculative and would require rigorous scientific investigation

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They may serve as an interface to modulate influences of endothelial and circulation-derived factors as well as the availability of cytokines and growth factors in the basal lamina