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Collectively, our findings demonstrate that the GPX4 inhibition by RSL3 in PTC cells induces cell death, ferroptosis, lipid peroxidation, increased intracellular ROS burden, and significantly impairs thyroid tumor cell migration, 3D PTC spheroid fotmation and results in reduced spheroid viability in vitro

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C.DwivediM.GaniA

Using ROS as a second messenger, NADPH oxidase 2 mediates macrophage senescence via interaction with NF-kappaB during Pseudomonas aeruginosa infection