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There was no change in viability between the control and CSE exposed cells at any timepoint (data not shown), which supports cells actively exporting GSH rather than it being released due to cell lysis
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For instance, studies have shown that chemotherapeutic agents like melphalan can directly disrupt ileal BA reabsorption (156), while other treatments reduce the abundance of key BA-metabolizing bacteria, such as those within the Clostridiales order
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doi: 10.1073/pnas.1702441114
