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10.3390/ijms22042105 112 RivaA.TogniS.GiacomelliL.FranceschiF.EggenhoffnerR.FeragalliB.et al (2017)

These findings are not contradictory to those in T cells (102) but rather reflect cell type-specific responses: SIN-induced T-cell apoptosis proceeds via caspase-3dependent mechanisms without Bcl-2 involvement, whereas in macrophages, apoptosis is mediated through ERK activation and modulation of Bcl-2 family proteins

Research shows that autoantibodies, such as anti-TPO, ANA, and anti-ENA, provide valuable early indicators of disease risk, enabling clinicians to intervene before overt symptoms develop